Description
the histamine H1 receptor in serum-starved HeLa cells at 10, 20, or 30 µM; inhibits PMA-induced increases in the levels of mRNA encoding Il-4 in RBL-2H3 cells at 50 or 150 µM; decreases LPS-induced increases in NO production in RAW 264.7 macrophages (IC50 = 27 µM); increases survival in a mouse model of CLP-induced sepsis at 2.5 or 5 mg/kg; reduces the number of sneezes and the extent of nasal redness, swelling, and watery rhinorrhea in a rat model of TDI-induced allergies at 20 mg/kg per day